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苏桂发

苏桂发 [教授]

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基本先容

苏桂发,理学博士,二级教授,1982-7参加工作,1987-7到广西师大工作。1996年开始独立引导研究生1998年晋升为教授,2001年获广西科技进步二等奖(排名第1)2003年获广西第七届青年科技奖,2003年入选广西高校百名中青年学科带头人资助计划,2005年入选广西新世纪十百千人才工程资助计划。2011年被遴选为有机化学专业博士研究生导师。获广西高校优秀教学成果二等奖一项(2012,排名第1)、一等奖两项(排名第220122017)2014年获广西高等学校教学名师奖。

主持20多项厅级以上科研课题的研究,在国内外公开发表学术论文150多篇,获授权中国发明专利8项。作为主编、副主编、参编公开出版教材及学习引导书9部,其中国家规划教材4部。

研究方向

杂环化合物的合成及生物活性研究、高效有机合成反应研究,特殊氨基酸以及构象限制多肽的合成、结构与性能研究。

讲授课程

高等有机化学(研究生),物理有机化学(研究生),有机化学(本科生)、有机合成(本科生) 、精细有机合成化学与工艺(本科生)。

论著专利

1. Hong-Yan Bi, Feng-Ping Liu, Cui Liang, Gui-Fa Su*, and Dong-Liang Mo*. A Tunable Route to Prepare ɑ,β-Unsaturated Esters and ɑ,β-Unsaturated-γ-Keto Esters through Copper-Catalyzed Coupling of Alkenyl Boronic Acids with Phosphorus Ylides, Adv. Synth. Catal. 2018, DOI: 10.1002/adsc.201701640.

2. Chun-Yang Zhao, Kun Li, Yu Pang, Jia-Qing Li, Cui Liang, Gui-Fa Su*, and Dong-Liang Mo*. Iodine(III) Reagent-Mediated Intramolecular Amination of 2-Alkenylanilines to Prepare Indoles,  Adv. Synth. Catal. 2018, DOI: 10.1002/adsc.201701551.

3. Xiang-Fei Kong, Feng Zhan, Guo-Xue He, Cheng-Xue Pan, Chen-Xi Gu, Ke Lu, Dong-Liang Mo,* and Gui-Fa Su*. Gold-Catalyzed Selective 6-exo-dig and 7-endo-dig Cyclizations of  Alkyn-Tethered Indoles To Prepare Rutaecarpine Derivatives, J. Org. Chem. 2018, 83(4), 2006- 2017.   

4. Xiao-Pan Ma, Kun Li, Si-Yi Wu, Cui Liang, Gui-Fa Su* and Dong-Liang Mo*. Construction of 2,3-quaternary fused indolines from alkynyl tethered oximes and diaryliodonium salts through a cascade strategy of N-arylation/ cycloaddition/[3,3]- rearrangement, Green Chem. 2017, 19(24), 5761–5766. Inside front cover, 2017 Green Chemistry Hot Articles. 

5. Ning Zou, Ji-Wen Jiao, Yu Feng,a Chun-Hua Chen, Cui Liang, Gui-Fa Su,* and Dong-Liang Mo.* Diastereoselective Synthesis of Nine-Membered Heterocycles via the Cycloaddition and Sequential Rearrangement of N-Vinyl Nitrones with Isocyanates, Adv. Synth. Catal. 2017, 359, 3545-3350.

6. Wei-Min Shi, Feng-Ping Liu, Zhi-Xin Wang, Hong-Yan Bi, Cui Liang, Li-Ping Xu,* Gui-Fa Su,* and Dong-Liang Mo.* Synthesis of 1-Vinyl/Aryl Benzotriazole 3-Oxides through Copper-Catalyzed C-N Bond Coupling Reaction, Adv. Synth. Catal., 2017, 359(16), 2741-2746.

7. Guo-Hai Zhang, Jing-Mei Yuan, Gang Qian, Chen-Xi Gu, Kai Wei, Dong-Liang Mo, Jiang-Ke Qin, Yan Peng, Zu-Ping Zhou, Cheng-Xue Pan*, and Gui-Fa Su*. Phthalazino[1,2-b]-quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak–Bcl-xl Complex Reorganization in Bladder Cancer Cells, J. Med. Chem. 2017, 60(16), 6853? 6866.

8. Chun-Hua Chen, Qing-Qing Liu, Xiao-Pan Ma, Yu Feng, Cui Liang, Cheng-Xue Pan, Gui-Fa Su,* and Dong-Liang Mo*. Copper-Catalyzed Selective N?Vinylation of 3?(Hydroxyimino)-indolin- 2-ones with Alkenyl Boronic Acids: Synthesis of N?Vinyl Nitrones and Spirooxindoles, J. Org. Chem. 2017, 82, 6417?6425.

9. Yan-Xiao Jiao, Ling-Ling Wu, Hai-Miao Zhu, Jiang-Ke Qin, Cheng-Xue Pan,* Dong-Liang Mo,* and Gui-Fa Su*. Tandem C–N Bonds Formation through Condensation and Metal-Free N-Arylation: Protocol for Synthesizing Diverse Functionalized Quinoxalines, J. Org. Chem. 2017, 82(8), 4407?14.

10. Guo-Xue He, Jing-Mei Yuan, Hai-Miao Zhu, Kai Wei, Ling-Yun Wang, Shi-Lin Kong, Dong-Liang Mo, Cheng-Xue Pan* and Gui-Fa Su*. Synthesis and antitumor evaluation of 2,3-diarylbenzofuran derivatives on HeLa cells, Bioorg. Med. Chem. Lett. 2017, 27, 1660– 1664.

11. Yan-Xiao Jiao, Xiao-Pan Ma, Gui-Fa Su* and Dong-Liang Mo*. Recent Advances in Arylation and Alkenylation of N–O bonds, Synthesis, 2017, 49, 933-959.

12. Xiao-Pan Ma, Jie-Feng Zhu, Si-Yi Wu, Chun-Hua Chen, Ning Zou, Cui Liang, Gui-Fa Su,*and Dong-Liang Mo*. Cycloaddition of Fluorenone N?Aryl Nitrones with Methylenecyclopropanes and Sequential 1,3-Rearrangement: An Entry to Synthesis of Spirofluorenylpiperidin-4-ones, J. Org. Chem. 2017, 82, 502?511.

13. Zhi-Xin Wang, Wei-Min Shi, Hong-Yan Bi, Xiao-Hua Li, Gui-Fa Su* and Dong-Liang Mo*. Synthesis of N-(2-Hydroxyaryl)benzotriazoles via Metal-Free O-Arylation and N?O Bond Cleavage, J. Org. Chem. 2016, 81, 8014-8021.

14. Chun-Yang Zhao, Liang-Gui Li, Qing-Rong Liu, Cheng-Xue Pan, Gui-Fa Su* and Dong-Liang Mo*. Synthesis of β-acetoxy alcohols by PhI(OAc)2-mediated metal-free diastereoselective β-acetoxylation of alcohols, Org. Biomol. Chem., 2016, 14, 6795–803.

15. Wei-Min Shi, Xiao-Pan Ma, Gui-Fa Su*, Dong-Liang Mo*. New developments of ketonitrones in organic synthesis, Org. Chem. Front. 2016, 3, 116–130.

16. Guo-Hai Zhang, Wen-Bin Xue, Yun-Feng An, Jing-Mei Yuan, Jiang-Ke Qin, Cheng-Xue Pan*, Gui-Fa Su*. Distinct novel quinazolinone exhibits selective inhibition in MGC-803 cancer cells by dictating mutant p53 function, Eur. J. Med. Chem. 2015, 95, 377-387.

17. Wei-Min Shi, Xiao-Pan Ma, Cheng-Xue Pan, Gui-Fa Su,* and Dong-Liang Mo*. Tandem C―O and C―N Bonds Formation Through O-Arylation and [3,3]-Rearrangement by Diaryliodonium Salts: Synthesis of N-Aryl Benzo[1,2,3]triazin-4(1H)-one Derivatives, J. Org. Chem. 2015, 80, 11175- 11183.

18. Xiao-Pan Ma, Wei-Min Shi, Xue-Ling Mo, Xiao-Hua Li, Liang-Gui Li, Cheng-Xue Pan, Bo Chen,* Gui-Fa Su,* and Dong-Liang Mo*. Synthesis of α,β-Unsaturated N-Aryl Ketonitrones from Oximes and Diaryliodonium Salts: Observation of a Metal-Free N-Arylation Process, J. Org. Chem. 2015, 80, 10098-10107.

19. Qing-Rong Liu, Cheng-Xue Pan, Xiao-Pan Ma, Dong-Liang Mo,* and Gui-Fa Su*. (Diacetoxyiodo)benzene–Mediated Reaction of Ethynylcarbinols: Entry to α,α-Diacetoxy Ketones and Glycerol Derivatives, J. Org. Chem. 2015, 80, 6496?6501.

20. Yan-Li Xu, Ying-Ming Pan,* Pei Liu, Heng-Shan Wang, Xiao-Yan Tian, and Gui-Fa Su*. Indium (III) chloride catalyzed conjugate addition reaction of alkynylsilanes to acrylate esters, J. Org. Chem. 2012, 77, 3557?3562.

21. 潘成学,苏桂发,孔石林,戴求资,朱海妙,刘晴晴。萘并[1,2-h][1,6]萘啶-3(4H)-酮类化合物及其制备方法和应用,中国发明专利号ZL 201610554316.4

22. 苏桂发,潘成学,钱刚,袁静梅,张国海,何国学。酞嗪并[1,2,b]喹唑啉-8-酮化合物及其制备方法和抗肿瘤药物中的应用,中国发明专利号ZL 201510969739.8

23. 潘成学,苏桂发,焦艳晓,吴玲玲,覃江克。2, 3-二取代喹喔啉衍生物的制备方法, 中国发明专利号ZL201410323633.6

24. 苏桂发,焦艳晓,潘成学,韦罗山,孔石林,黄婉云。川芎嗪茋类衍生物及其制备方法与应用, 中国发明专利号ZL 201410075473.8

25. 苏桂发,郑志兵,农娟,李松,王莉莉,覃江克,潘成学,唐煌,邓业成。新的哌嗪和高哌嗪类衍生物及其制备方法和应用,中国发明专利号ZL 201110324535.0.

26. 苏桂发,潘成学,冯凯熙,戴支凯,覃江克,唐煌,刘华钢。2,3-二氧乙基-5-甲基-8,9-二甲氧基苯并菲啶衍生物及其制备方法和应用,中国发明专利号ZL 201210381432.2.

科研项目

1. 基于片段的靶向拓扑异构酶I抗肿瘤新化学实体的设计、结构优化及其活性研究(国家自然科学基金课题, 项目编号21462008, 53, 2015.01-2018.12, 主持).

2. 基于靶标药效团模型的AromathecinsLuotonin A的结构改造和构效关系研究(广西自然科学基金重点项目, 项目编号2017GXNSFDA198045, 40, 2017.09-2021.09, 主持)

3. Aromathecins结构改造及其抗肿瘤活性研究(广西医药人才小高地资助专项基金课题, 项目编号201705, 6, 2017.01-2019.12, 主持)

获奖情况

广西科技进步二等奖(排名第一, 2001). 广西青年科技奖(2003, 第七届).

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