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Keguang CHENG

Contact Information

Position: Professor

Tel: +86-0773-2120958

Email: kgcheng2008@126.com

Address:


Academic Achievement

1. Cheng Ke-guang#, Su Chun-hua#, Huang Jia-yan, Wang Heng-shan, Liu Jun***, Zheng Yuan-ting**, Chen Zhen-feng*. Synthesis and cytotoxic evaluation of several oleanolic acid-uracil/thymine conjugates. MedChemComm, 2016, 7(5): 972-981.

2. Cheng Ke-guang,Su Chun-hua, Huang Jia-yan,Liu Jun**,Zheng Yuan-ting***, Chen Zhen-feng*. Conjugation of uridine with oleanolic acid derivatives as potential antitumor agents. Chem Biol Drug Des, 2016, 88(3): 329-340.

3. Mo Wei-bin#, Su Chun-hua#, Huang Jia-yan, Liu Jun**, Chen Zhen-feng*, Cheng Ke-guang*. Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity. Chem Cent J, 2016, 10(1): 69.

4. Li Dahong, Han Tong, Liao Jie, Hu Xu, Xu Shengtao, Tian Kangtao, Gu Xiaoke, Cheng keguang***, Li Zhanlin, Hua Huiming*, Xu Jinyi**. Oridonin, a promising ent-Kaurane diterpenoid lead compound. Int J Mol Sci, 2016, 17(9): 1395.

5. Li Dahong, Han Tong, Xu Shengtao, Zhou Tingting, Tian Kangtao, Hu Xu, Cheng Keguang***, Li Zhanlin, Hua Huiming*, Xu Jinyi**. Antitumor and antibacterial derivatives of Oridonin: a main composition of Dong-Ling-Cao. Molecules, 2016, 21(5): 575.

6. 黄家艳黎淑宁廖雯菲邓胜平*程克光*O-炔丙基-N,N-(2-氯乙基)-4-氨基苯酚的合成与表征合成化学, 2016, 24(6): 522-524.

7. Cheng Ke-guang, Su Chun-hua, Yang Lin-dong, Liu Jun**, Chen Zhen-feng*. Synthesis of oleanolic acid dimers linked at C-28 and evaluation of anti-tumor activity. Eur J Med Chem, 2015, 89: 480-489.

8. 程克光*初相伍刘观艳苏春华邓胜平潘红梅. 3-取代雌二醇-嘧啶类衍生物的合成与抗肿瘤活性中国药科大学学报, 2014, 45(1): 26-32.

9. 程克光*张江玉刘观艳初相伍凌丹姚国义. 17-取代雌二醇-嘧啶类衍生物的合成与体外抗肿瘤活性研究中国新药杂志, 2014, 23(2): 219-225.

10. 苏春华程克光*初相伍田小艳黄晓超王恒山邹连珍齐墩果酸-α-氨基膦酸酯衍生物的合成与抗肿瘤活性研究中国实验方剂学杂志, 2014, 20(8): 123-128.

11. 刘观艳程克光*邓胜平刘延成初相伍陈健辉马璐雌二醇酯类衍生物的合成与抗肿瘤活性研究广西师范大学学报自然科学版, 2013, 31(1): 62-66.

12. Cheng  Keguang, Liu Jun, Sun Hongbin*, Bokor ?va, Czifrák Katalin, Kónya Bálint, Tóth Marietta, Docsa Tibor, Gergely Pál, Somsák  László**. Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase. New J Chem, 2010, 34: 1450-1464.

13. Cheng Keguang, Liu Jun, Sun Hongbin**, Xie Juan*. Synthesis of Nucleoside Conjugates as Potential Inhibitors of Glycogen Phosphorylase. Synthesis,2010, 1046-1052.

14. Cheng Keguang, Liu Jun, Sun Hongbin**, Xie Juan*. Synthesis of oleanolic acid dimers as inhibitors of glycogen phosphorylase. Chem Biodivers,2010, 7(3): 690-697.

15. Cheng Keguang, Wang Chao, Liu Jun, Xie Juan**, Sun Hongbin*. Synthesis and evaluation of C-28 oleanolic acid derivatives as inhibitors of glycogen phosphorylase. Lett Drug Des Discov, 2010, 7(2): 116-121.

16. Cheng Keguang, Liu Jun, Liu Xiaofeng, Li Honglin, Sun Hongbin**, Xie Juan*. Synthesis of glucoconjugates of oleanolic acid as inhibitors of glycogen phosphorylase. Carbohyd Res, 2009, 344(7): 841-850.

17. Cheng Keguang, Zhang Pu, Liu Jun, Xie Juan, Sun Hongbin*Practical synthesis of bredemolic acid, a natural inhibitor of glycogen phosphorylase. J Nat Prod, 2008, 71(11): 1877-1880.

18. Lu Jing#, Lu Dong#, Zhang Xiaochen, Bi Yi, Cheng Keguang, Zheng Mingyue*, Luo Xiaomin*Estimation of elimination half-lives of organic chemicals in humans using gradient boosting machine. BBA-GEN Subjects, 2016, 1860(11): 2664-2671.

19. Li Dahong, Hu xu, Han Tong, Xu Shengtao, Zhou Tingting, Wang Zhenzhong**, Cheng Keguang, Li Zhanlin, Hua Huiming*, Xiao Wei, Xu Jinyi***. Synthesis, biological activity, and apoptotic properties of NO-Donor/Enmein-Type ent-Kauranoid hybrids. Int J Mol Sci, 2016, 17(6): 747.

20. Zhao Nan#, Tian Kang-tao#, Cheng Ke-guang, Han Tong, Hu Xu, Li Da-hong*, Li Zhan-lin, Hua Hui-ming*. Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine. Bioorg Med Chem, 2016, 24(13): 2971-2978.

21. Bi Yi#, Yang Xiao#, Zhang Tingting, Liu Zeyun, Zhang Xiaochen, Lu Jing, Cheng Keguang, Xu Jinyi, Wang Hongbo, Lv Guangyao, Lewis Peter John, Meng Qingguo*, Ma Cong**. Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives. Eur J Med Chem, 2015, 101: 71-80.

22. Shao Tengfei, Zheng Yuanting*, Zhao Bei, Li Tao, Cheng Keguang, Cai WeiMin. Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity. Sci China Life Sci, 2014, 57(10): 1011-1017.

23. Wang Yingchun*, Li Xiuying, Li Yajun, Pan Yingming, Cheng Keguang, Wang Hengshan*. Simultaneous reduction of aldehyde group to hydroxymethyl group in palladium-catalyzed Suzuki Cross-coupling reaction. Chem Res Chin Univ, 2014, 30(4): 614-618.

24. Peyrat Sandrine, Cheng Keguang, Xie Juan*Synthesis of C-glucosyl aminooxy esters. Synthesis, 2013, 45(19): 2737-2744.

25. Liang Zhongjie#, Zhang Liying#, Li Lianchun, Liu Jun, Li Hongling, Zhang Luyong, Chen Limin, Cheng Keguang, Zheng Mingyue, Wen Xiaoan, Zhang Pu, Hao Jia, Gong Yanchun, Zhang Xia, Zhu Xiaoyun, Chen Jun, Liu Hong, Jiang Hualiang, Luo Cheng*, Sun Hongbin**. Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies. Eur J Med Chem, 2011, 46(6): 2011-2021.

26. Wen Xiaoan, Sun Hongbin*, Liu Jun, Cheng Keguang, Zhang Pu, Zhang Liying, Hao Jia, Zhang Luyong, Ni Peizhou, Zographos Spyros E., Leonidas Demetres D., Alexacou Kyra-Melinda, Gimisis Thanasis, Hayes Joseph M., Oikonomakos Nikos G**. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-Activity relationships, and X-ray crystallographic studies. J Med Chem, 2008, 51(12): 3540-3554.

27. Wen Xiaoan, Xia Jun, Cheng Keguang, Zhang Liying, Zhang Pu, Liu Jun, Zhang Luyong, Ni Peizhou, Sun Hongbin*. Pentacyclic triterpenes. Part 5: Synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases. Bioorg Med Chem Lett, 2007, 17(21): 5777-5782.

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