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陈振锋 

点击数:2812 来源:澳门赌搏网站大全 编辑: 录入:人员机构 更新时间:2018-11-23

陈振锋 [教授]

陈振锋

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基本先容

博士,1969年11月生于广西北流市。2001年6月毕业于南京大学无机化学专业,获理学博士学位。2001年晋升副教授,2003年被破格晋升教授。2004年被评为广西新世纪“百千万人才工程”第二层次人选,教育部“新世纪优秀人才支撑计划”人选。2006-2007到加拿大University of British Columbia化学系Chris Orvig教授实验室作访问研究。2011年被聘为广西首批“八桂学者”(药物化学)。现任澳门赌搏网站大全副院长、药用资源化学与药物分子工程教育部重点实验室常务副主任,广西药用资源化学与药物分子工程实验室----省部共建国家重点实验室培育基地常务副主任。主要承担本科生《无机化学》和研究生的《现代配位化学》等课程的教学工作。作为硕士生导师,已引导或合作硕士研究生40多名,独立或合作引导博士研究生8名。先后主持973计划前期研究专项1项,国家自然科学基金项目3项,教育部”创新团队发展计划”项目1项,教育部重点项目2项,教育部“新世纪优秀人才支撑计划”资助项目1项,广西自然科学基金项目4项。作为第二成员参与国家自然科学基金地区基金联合资助项目1项,973计划前期研究专项各3项。近年来已在《Chem. Eur. J.》,《Chem. Commun.》,《Analytical Chemistry》, 《Inorg. Chem.》,《Organometallics》,《CrystEngComm》,《Dalton Trans.》,《J. Biol. Inorg. Chem.》,《J. Inorg. Biochem.》,《Eur. J. Med. Chem.》《Bioorg. & Med. Chem. Lett.》,《Anti-Cancer Agents in Medicinal Chemistry》《Eur. J. Inorg. Chem.》等国际、国内刊物正式发表SCI收录论文120余篇,他人引用1100余次。作为第一完成人2012年获广西自然科学奖三等奖1项,作为第二完成人2003年获广西科技进步一等奖1项。现任广西自然科学基金委员会常务委员,《广西师范大学学报》编委和《Crystal & Growth Design》,《CrystEngComm》,《Dalton Trans.》,《Evidence Based Complementary and Alternative Medicine》,《Mini-Reviews in Medicinal Chemistry》,《Eur. J. Med. Chem.》《Bioorg. & Med. Chem. Lett.》,《Inorganic Chemistry Communications》,《Inorg. Chim. Acta》,《Appl. Organometal. Chem.》,《J. Coord. Chem.》,《中国科学》,《化学学报》,《结构化学》,《有机化学》等近20种刊物的审稿人。

研究方向

基于中药活性成分金属抗肿瘤药物、抗糖尿病药物的研究。

论著专利

1.Pei Liu, Heng-shan Wang, Ying-ming Pan,* Wei-long Dai, Hong Liang and Zhen-Feng Chen*. The first palladium-catalyzed 1,4-addition of terminal alkenes to acrylate esters. Chem. Commoun., 2013, 49, 5295-5297.

2. Yan-Cheng Liu, Zhen-Feng Chen*, Xiao-Yan Song, Yan Peng, Qi-Pin Qin, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dibromo-8-quinolinolato- lanthanides. European Journal of Medicinal Chemistry, 2013, 59, 168-175.

3. Zhen-Feng Chen*, Yun-Qiong Gu, Xiao-Yan Song, Yan-Cheng Liu, Yan Peng, Hong Liang*. Synthesis, crystal structure, cytotoxicity and DNA interaction of 5,7-dichloro-8- quinolinolato-lanthanides. European Journal of Medicinal Chemistry, 2013, 59, 194-202.

4. Zhen-Feng Chen*, Yan Peng, Yun-Qiong Gu, Yan-Cheng Liu, Mei Liu, Ke-Bin Huang, Kun Hu and Hong Liang*. High antitumor activity of 5,7-dihalo-8- quinolinolato tin(IV) complexes. European Journal of Medicinal Chemistry, 2013, 2013, 62,51-58.

5. Ke-Bin Huang, Zhen-Feng Chen*, Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Guo-Hai Zhang, Hong Liang*. Platinum(II) complexes with mono-aminopho- sphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity. European Journal of Medicinal Chemistry, 2013, 63, 76-84.

6. Ke-Bin Huang, Zhen-Feng Chen,* Yan-Cheng Liu, Zhu-Quan Li, Jian-Hua Wei, Meng Wang, Xiao-Li Xie, and Hong Liang*. Platinum(II) complexes containing aminophosphonate esters: synthsis, characterization, cytotoxicity and action mechanism. European Journal of Medicinal Chemistry, 2013, 64,554-561.

7. Yan Peng, Min-Min Zhang, Zhen-Feng Chen,* Kun Hu, Yan-Cheng Liu, Xia Chen and Hong Liang*. Synthesis, characterization and interaction with biomolecules of platinum(II) complexes with shikimic acid-based ligands. Bioinorganic Chemistry and Applications, Volume 2013, Article ID 565032, 12 pages.

8.Zhen-Feng Chen*, Yan-Fang Shi, Yan-Cheng Liu, Xue Hong, Bo Geng, Yan Peng, Hong Liang*, TCM active ingredient oxoglaucine metal complexes: Crystal structure, cytotoxicity and interaction with DNA. Inorganic Chemistry, 2012, 51, 1998-2009.

9.Huang Tang, Hai-Tao Zhao, Shu-Ming Zhong, Zhi-Yu Wang, Zhen-Fen Chen*, Hong Liang*, Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. Bioorganic & Medicinal Chemistry Letters, 2012, 22, 2257-2261.

10.Zhen-Feng Chen*, Yan-Cheng Liu, Yan Peng, Xue Hong, Hong-Hong Wang, Min-Min Zhang, Hong Liang. Synthesis, characterization, and in vitro antitumor properties of gold(III) compounds with the traditional Chinese medicine (TCM) active ingredient liriodenine. J. Biol. Inorg. Chem., 2012, 17(2), 247-261.

11.Zhen-Feng Chen*, Li Mao, Li-Min Liu, Yan-Cheng Liu,Yan Peng, Xue Hong, Hong-Hong Wang, Hua-Gang Liu, Hong Liang*. Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) matrine with Ga(III), Au(III), Sn(IV) ions, and DNA binding studies. J. Inorg. Biochem., 2011, 105, 171-180.

12.Zhen-Feng Chen*, Xiao-Yan Song, Yan Peng, Xue Hong, Yan-Cheng Liu, Hong Liang. High cytotoxicity of dihalo-substituted 8-quinolinolato-lanthanides. Dalton Trans., 2011, 40,1684-1692.

13. Zhen-Feng Chen*, Ming-Xiong Tan, Yan-Cheng Liu, Yan Peng, Hong-Hong Wang, Hua-Gang Liu and Hong Liang*. Synthesis, Characterization and Preliminary Cytotoxicity Evaluation of Five Lanthanide(III)-Plumbagin Complexes. J. Inorg. Biochem., 2011, 105,308-316.

14. Huang Tang, Li-Zhen Zhao, Hao-Tao Zhao, Shi-Liang Huang, Shu-Ming Zhong, Jiang-Ke Qin, Zhen-Feng Chen,* Zhi-Shu Huang, Hong Liang. Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase- induced b-amyloid aggregation inhibitors. European Journal of Medicinal Chemistry, 2011, 46, 4970-4979.

15. Zhen-Feng Chen*, Hong Liang*, Progresses in TCM Metal-Based Antitumour Agents, Anti-Cancer Agents in Medicinal Chemistry, 2010, 10, 412-423.

16. Zhen-Feng Chen*, Yan-Cheng Liu, Li-Min Liu, Heng-Shan Wang, San-Hai Qin, Bo-Long Wang, He-Dong Bian, Bin Yang, Hoong-Kun Fun, Hua-Gang Liu, Hong Lian and Chris Orvig, Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies, Dalton Trans.,2009,(2): 262-272.

17.Yan-Cheng Liu, Zhen-Feng Chen*, Li-Min Liu, Yan Peng, Xue Hong, Bin Yang,Hua-Gang Liu,Hong Liang and Chris Orvig, Divalent later transition metal complexes of the traditional chinese medicine (TCM) liriodenine: coordination chemistry, cytotoxicity and DNA binding studies, Dalton Trans., 2009, (48): 10813-10823.

18.Zhen-Feng Chen*, Ming-Xiong Tan, Li-Min Liu, Yan-Cheng Liu, Heng-Shan Wang,Bin Yang,Yan Peng, Hua-Gang Liu, Hong Liang and Chris Orvig, Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry, Dalton Trans.,2009, (48):10824-10833.

19.Meryn L. Bowen, Zhen-Feng Chen, Adrienne M. Roos, Ripen Misri, Urs Hafeli, Michael J. Adam and Chris Orvig, Long-chain rhenium and technetium glucosamine conjugates, Dalton Trans., 2009, 9228-9236.

20.Zhen-Feng Chen*, Shu-Feng Zhang, Hai-Sheng Luo, Brendan F. Abrahams and Hong Liang. Ni2(R*COO)4(4,4’-bipy)2----a robust homochrial quartz-like network with large chiral channels. CrystEngComm, 2007, 9, 7-29.

21. Zhen-Feng Chen*, Zhi-Li Zhang,Yu-Hui Tan,Yun-Zhi Tang,Hoong-Kun Fun, Zhong-Yuan Zhou, Brendan F. Abrahams and Hong Liang. Coordination polymers constructed by linking metal ions with azodibenzoate anions. CrystEngComm, 2008, 10, 17-231.

22. Zhi-Rong Qu, Zhen-Feng Chen*, et al. The first highly stable homochiral olefin-copper(I) 2D coordination polymer grid based on quinine as a building block.Organometallics, 2003,22,2814-2816.

23. Zhen-Feng Chen, Ren-Gen Xiong, Jing Zhang, Xue-Tai Chen, Zi-Ling Xue, Xiao-Zeng You. 2D molecular square grid with strong blue fluorescent emission: a complex of norfloxacin with Zinc(II). Inorganic Chemistry,2001,40(16),4075-4077.

24. Zhen-Feng Chen, Ren-Gen Xiong, Abrahams Brendan F., Xiao-Zeng You, Chi-Ming Che. An unprecedented six-fold anion-type chiral diamondoid-like eight-coordinate Cd(II) coordination polymer with a second-order nonlinear optical effect. Dalton Trans, 2001,(17),2453-2455.


科研项目

1. 国家自然科学基金面上项目:雌激素靶向配体调控的高活性卤代喹啉-镧系系列抗肿瘤配合物(21271051),2013/1-2016/12,78万元。

2. 教育部创新团队项目:天然活性物质的发现、结构改造与功能(IRT1225), 2013/1-2015/12,450万元。

3. 广西首批八桂学者项目:药物化学,2011/11-2016/10,500万元。

4.广西自然科学基金重点项目: 基于中药活性成分氧化阿朴菲生物碱抗肿瘤金属药物前期研究(2012GXNSFDA053005), 2012/4-2014/3,25万元。


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