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王恒山 

点击数:1500 来源:澳门赌搏网站大全 编辑: 录入:人员机构 更新时间:2018-11-23

王恒山 [教授]


----个人基本信息----

姓名:

王恒山

出生年月:

1965.4

籍贯:

浙江

学历:

博士

职称:

教授

专业:

有机化学

  

---教育和主要工作经历---

  2000年毕业于兰州大学,获理学博士学位, 2004任广西师范大学化学化工学院教授, 200611月赴美国杰克逊州立大学访问广西“特聘专家”、广西“新世纪十百千人才工程”第二层次人选,广西师范大学“药用资源化学与药物分子工程”省部共建国家重点实验室副主任、“西南民族药2011协同创新中心”秘书长。

先后主持973前期研究专项1项、国家自然科学基金项目4项、国际合作项目1项、国家科技支撑计划项目子课题1项,以及高等学校博士学科点专项基金、广西自然科学基金重点项目等其他省部级、厅级课题12项;以第三成员参加国家自然科学基金重点项目1项、973前期研究专项1项。共在Org. Lett., Green Chem.,Chem. Commun.,Bioconjugate Chem., Eur. J. Med. Chem., Adv. Synth. Catal., Bioorg. Med. Chem, Phytochemistry, Phytomedicine, Food Chemistry, Food Res. Int., LWT - Food Sci. Technol. 化学和药学类期刊发表论文260余篇其中150余篇被SCI收录JCR一、二区论文40。研究成果在Chem. Rev., Chem. Soc. Rev.J. Am. Chem. Soc., ACS Catalysis Green Chem.刊物被他人正面引用1200单篇最高引用频次180次。参编英文专著1部。获得广西自然科学奖二等奖2项(排名第一、六)、广西科技进步二等奖3项(排名第二、三、五)、广西自然科学三等奖1项(排名第一)和广西科技进步三等奖(排名第五)各1项。获8项国家发明专利授权,部分新产品已被美国Sigma-Aldrich等企业采用。在国际和全国学术会议做邀请报告5次。已培养博士2名、硕士46名。

中国化学会员、中国化工学会专家库专家,广西化学化工学会专家库专家,广西化学化工学会理事,韶关市企业创新发展专家库专家,《广西植物》、《广西师范大学学报》编委和Chem. Sci., J. Med. Chem., Adv. Synth. Catal., J. Org..Chem., Eur. J. Med.Chem., Phytomed., Phytochem.,J. Med. Food., Pharm. Bio., New J. Chem.., Molecular Nutrition&Food Research,20余种SCI刊物的特约审稿人。


---讲授的课程---

天然药物化学、波谱解析、天然产物开发与利用、中药鉴定及质量控制、表征技术


---研究领域--- 

主要研究和感兴趣的领域:

中药与天然药物化学、手性药物的结构改造与分离分析研究,功能分子的合成方法学。

  

---近年研究项目--- 

1973计划前期研究专项(No.2011CB512005):基于广西主产中药活性成分的手性氨基膦酸酯基抗肿瘤和抗病毒药物的前期研究。

2、国家自然科学基金(No. 81760626): 卷柏属瑶药中新型PDE4 / MMPs双靶点抑制剂的协同抗肿瘤耐药机制。

3、国家自然科学基金(No. 81260472): 天然萜烷和氨基酸背景()磷酰胺衍生物的手性与肿瘤细胞抑制作用相互关系。

4、广西重点研发计划(No.2017AB44061: 基于样品库中新型肿瘤和病毒靶点抑制剂筛查的十种瑶药标准制定

5、高等学校博士学科点专项科研基金博导类资助课题(No.20134504110002: 三类天然骨架含氮磷小分子抗肿瘤药物的串联反应合成与活性研究。

6、国家自然科学基金重点项目(No.21431001: 基于中药活性成分的金属抗肿瘤配合物研究(第三成员)


---企业研发项目---

1. 三金片浸膏主要化学成分分离鉴定及含量测定用化学对照品纯化制备研究

2. 壮药羊开口主要化学成分分离鉴定和含量测定用化学对照品纯化制备研究

3. 丹参酮系列中药注射剂的中药现代化研究


---科研奖励--- 

1. 王恒山、潘英明、梁英、陈振锋、张业、徐艳丽,若干绿色催化体系在五元氮杂环药物骨架构筑及手性氮碳磷键侧链修饰中的应用,广西科技进步奖二等奖,2016

2.王恒山、潘英明、赵书林、梁英、王凯、何春欢,特色桂药抑制活性氧自由基损伤功效物质基础及作用机制的研究与应用,广西自然科学奖三等奖,2012

3.潘英明、王恒山、吴强、黄宇平、杨韶平、张业、王迎春、陈键泉、黄晓超. 松香手性产品深加工技术及其生产工艺的研发与应用,广西科技进步奖二等奖,2015

4.方显明、谢金鲜、覃振林、方兴、王恒山、唐友明、兰树彬、欧阳熙林、韦斌,广西特色壮药经血宁胶囊的研发与临床应用,广西科技进步奖二等奖,2014

5.赵书林、叶芳贵、卢 昕、田建袅、李舒婷、王恒山,微流控芯片和毛细管电泳新方法及其在单细胞和体液分析中的应用研究,广西自然科学奖二等奖,2010

6.赵书林、李舒婷、王恒山等,毛细管电泳新技术及其在生物和药物分析中的应用研究,广西科技进步奖二等奖,2007

7. 张业、义祥辉、覃雯、潘英明、王恒山、程忠泉、陈力健,基于白藜芦醇骨架改造的化合物的制备及其抗氧化、抗肿瘤活性研究,广西科技进步奖三等奖,2014


---代表性成果--- 

[1] Yan He, Yingchun Wang, Xinping Liang, Bin Huang, Hengshan Wang,* and Ying-Ming Pan*. Palladium-Catalyzed Three-Component Reaction: A Novel Method for the Synthesis of N-Acyl Propiolamides . Organic letters. 2018,  20, 22, 7117-7120

[2] Huang, X. Y., Ding, R., Mo, Z. Y., Xu, Y. L., Tang, H. T., Wang, H. S. *, Chen, Y. Y., & Pan, Y. M.* (2018). Photocatalytic Construction of S–S and C–S Bonds Promoted by Acridinium Salt: An Unexpected Pathway To Synthesize 1, 2, 4-Dithiazoles. Organic Letters. 2018, 20, 4819?4823

[3] Jiu-ling Li, Wei-ze Li, Ying-chun Wang, Qiu Ren, Heng-shan Wang,* and Ying-ming Pan*. Palladium(II)-Catalyzed C-C and C-O Bonds Formation for the Synthesis of C1-Benzoyl Isoquinolines from Isoquinoline N-Oxides and Nitro Alkenes. Chem. Commun., 2016, 52, 10028-10031.

[4] Jiu-ling Li, Ying-chun Wang, Wei-ze Li, Heng-shan Wang,* Dong-liang Moa and Ying-ming Pan*. Facile synthesis of 2,5‐disubstituted oxazoles via a coppercatalyzed cascade reaction of alkenes with azides. Chem. Commun., 2015, 51, 17772-17774.

[5] Huang, X., Huang, R., Gou, S.*, Wang, Z., Wang, H*. Anticancer Platinum(IV) Prodrugs Containing Monoaminophosphonate Ester as a Targeting Group Inhibit Matrix Metalloproteinases and Reverse Multidrug Resistance. Bioconjugate Chem., 2017, 28 (4), 1305-1323.

[6] Huang, X., Huang, R., Gou, S.*, Wang, Z., Liao, Z., & Wang, H*. Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt (IV) Moiety with a Unique Mode of Action. Bioconjugate Chem., 2016, 27(9): 2132-2148. 

[7] Xie, Y. Y., Wang, Y. C., He, Y., Hu, D. C., Wang, H. S.*, & Pan, Y. M.* (2016). Catalyst-Free Synthesis of Fused 1, 2, 3-Triazole and Isoindoline Derivatives via Intramolecular Azide-Alkene Cascade Reaction. Green Chem., 2017, 19, 656–659

[8] He, Y., Wang, Y. C., Hu, K., Xu, X. L., Wang, H. S.*, & Pan, Y. M.*. Palladium-Catalyzed Synthesis of 5-Iminopyrrolones through Isocyanide Double Insertion Reaction with Terminal Alkynes and Water. J. Org. Chem., 2016, 81(23), 11813-11818

[9] Yan-li Xu, Ying-Ming Pan,* Qiang Wu, Heng-Shan Wang*, Pei-zhen Liu. Regioselective Synthesis of 1,3,5-Substituted Benzenes via the InCl3/2-iodophenol- Catalyzed Cyclotrimerization of Alkynes. J. Org. Chem. 2011, 76(20), 8472-08476.

[10] Ying-Chun Wang, Yu-Yang Xie, Hong-En Qu, Heng-Shan Wang*, Ying-Ming Pan*, Fu-Ping Huang. Ce(OTf)3-catalyzed [3+2] cycloaddition of azides with nitroolefins: regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles. J. Org. Chem., 2014, 79, 4463?4469.

[11] Li, J. L., Hu, D. C., Liang, X. P., Wang, Y. C., Wang, H. S.*, & Pan, Y. M.*. Praseodymium (III)-Catalyzed Regioselective Synthesis of C3-N-substituted Coumarins with Coumarins and Azides. J. Org. Chem., 2017, 82, 9006?9011.

[12] Yingchun Wang, Jiuling Li, Yan He, Yuyang Xie, Hengshan Wang,* and Yingming Pan,* Synthesis of Polysubstituted Imidazoles and Pyridines via Samarium(III) Triflate-Catalyzed [2+2+1] and [4+2] Annulations of Unactivated Aromatic Alkenes with Azide. Adv. Synth. Catal., 2015, 357, 3229– 3241

[13] Yu-Yang Xie, Ying-Chun Wang, Hong-En Qu, Xian-Chun Tan, Heng-Shan Wang*, Ying-Ming Pan*. Regioselective synthesis of β-Aryl enaminones and 1,4,5-trisubstituted 1,2,3-triazoles from chalcones and benzyl azides. Adv. Synth. Catal., 2014, 356, 33473355.

[14] Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Heng-Shan Wang*, Dong Liang*, Cytotoxic Triterpenoid Saponins from Lysimachia foenum-graecum. Phytochemistry, 2017, 136 , 165-174

[15] Wei-Na Yao, Ri-Zhen Huang, Jing Hua, Bin Zhang, Chun-Gu Wang, Dong Liang,,* and Heng-Shan Wang,* Selagintamarlin A, A 1H-2-Benzopyran Selaginellin Analogue Possessing an Unprecedented Skeleton from Selaginellatamariscina. ACS Omega, 2017, 2 (5), pp 2178–2183

[16] Zhang, B., Huang, R., Hua, J., Liang, H., Pan, Y., Dai, L., Liang D* & Wang, H*. (2016). Antitumor lignanamides from the aerial parts of Corydalis saxicola. Phytomedicine, 23(13), 1599-1609.

[17] Ri-Zhen Huang, Xiao-Chao Huang, Bin Zhang, Hai-Yang Jia, Zhi-Xin Liao*, Heng-Shan Wang*. 16-O-caffeoyl-16-hydroxylhexadecanoic acid, a medicinal plant-derived phenylpropanoid, induces apoptosis in human hepatocarcinoma cells through ROS-dependent endoplasmic reticulum stress. Phytomedicine, 2018, 41, 33–44

[18] Yuan Zhu, Ri-Zhen Huang, Chun-Gu Wang, Xi-Lin Ouyang, Xiao-Teng Jing, Dong Liang*, and Heng-Shan Wang*.New inhibitors of matrix metalloproteinases 9 (MMP-9): lignans from Selaginella moellndorffii. Fitoterapia,2018,130,281–289

[19] Huang, R. Z., Zhang, B., Wang, C. G., Xu, X. J., Du, Y., Liao, N., Liao Z. X., * & Wang, H. S. *. A pentacyclic triterpene derivative possessing polyhydroxyl ring A suppresses growth of HeLa cells by reactive oxygen species-dependent NF-κB pathway. European Journal of Pharmacology. 2018, 838, 157–169

[20] Jiang, W., Huang, R. Z., Zhang, J., Guo, T., Zhang, M. T., Huang, X. C., Zhang, B., Liao Z. X.,* Sun. J.,* & Wang, H. S.* (2018). Discovery of antitumor ursolic acid long-chain diamine derivatives as potent inhibitors of NF-κB. Bioorganic Chemistry, 79, 265-276.

[21] Chun-Gu Wang, Wei-Na Yao, Bin Zhang, Jing Hua, Dong Liang*, Heng-Shan Wang*. Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration. Bioorganic & Medicinal Chemistry Letters 28 (2018) 2413–2417

[22] Lu-Mei Dai, Ri-Zhen Huang, Bin Zhang, Jing Hua, Hai-Bing Liao, Heng-Shan Wang*, Dong Liang*, Three new triterpenoid saponins from the aerial parts of Lysimachia foenumgraecum. Phytochemistry Letters, 2017, 22, 133–137

[23] Cai Yi Wang, Ji Sun Lee, Xiang Dong Su, Hong Xu Li, Sang Kook Lee, Heng-Shan Wang* Young Ho Kim* and Seo Young Yang*. Three new constituents from the aerial parts of Tetrastigma hemsleyanum and their cytotixic and soluble epoxide hydrolase inhibitory activities. Phytchem. Lett., 2018, 27, 25–29

[24] Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes. Org. Biomol. Chem., 2012, 10, 4696–4698.

[25] Xu Wang, Ying-ming Pan*, Xiao-chao Huang, Zhong-yuan Mao and Heng-shan Wang*. A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents. Org. Biomol. Chem., 2014, 12, 2028-2032

[26] Ying-chun Wang, Yu-yang Xie, Xian-chun Tan, Heng-shan Wang*, Ying-ming Pan*. Sc(OTf)3-mediated 1,3-dipolar cycloaddition-ring cleavage-rearrangement: a highly stereoselective access to Z-beta-enaminonitriles. Org. Biomol. Chem., 2015, 13, 513?519.

[27] Xiao-Chao Huang, Xiaochao Huang, Rizhen Huang, Zhimei Wang, Lingxue Li, Shaohua Gou*, Zhixin Liao, Heng-Shan Wang*. Pt(IV) complexes conjugating with chalcone analogue as inhibitors of microtubule polymerization exhibited selective inhibition in human cancer cells. Eur. J. Med. Chem.,  2018, 146, 435-450

[28] Xiaochao Huang, Shixian Hua, Rizhen Huang, Zhikun Liu, Shaohua Gou* , Zhimei Wang, Zhixin Liao, Hengshan Wang**. Dual-targeting antitumor hybrids derived from Pt(IV) species and millepachine analogues. Eur. J. Med. Chem., 2018, 148, 1-25

[29] Huang, R. Z., Liang, G. B., Huang, X. C., Zhang, B., Zhou, M. M., Liao, Z. X. *, & Wang, H. S*. Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. Eur. J. Med. Chem., 2017, 138, 979-992

[30] Huang, X., Huang, R., Gou, S.*, Wang, Z., Wang, H. S.*. synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents. Eur. J. Med. Chem., 2017, 132, 11-25.

[31] Jian-Mei Qin, Ri-Zheng Huang, Xiao-Chao Huang, Gui-Yang Yao, Ying-Ming Pan? and Heng-Shan Wang?. Terminal functionalized thiourea-containing dipeptides as multidrug- resistance reversers that target 20S proteasome and cell proliferation. Eur. J. Med. Chem., 2017, 126, 259-269

[32] Man-Yi Ye, Gui-Yang Yao, Ying-Ming Pan, Zhi-Xin Liao, Ye Zhang, Heng-Shan Wang*. Synthesis and antitumor activities of novel α-aminophosphonate derivatives containing an alizarin moiety. Eur. J. Med. Chem., 2014, 83, 116–128

[33] Jian-Fei Li, Ri-Zhen Huang, Gui-Yang Yao, Man-Yi Ye, Heng-Shan Wang*, Ying-Ming Pan*, Jing-Teng Xiao. Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents. Eur. J. Med. Chem., 2014, 86, 175188.

[34] Hong-En Qu , Ri-Zhen Huang, Gui-Yang Yao, Jiu-Ling Li, Man-Yi Ye, Heng-Shan Wang*, Liangxian Liu*. Synthesis and pharmacological evaluation of novel bisindole derivatives bearing oximes moiety: Identification of novel proapoptotic agents, Eur. J. Med. Chem., 2015, 95, 400?415.

[35] Xiao-Chao Huang, Le Jin, Meng Wang, Dong Liang, Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan, Heng-Shan Wang*. Design, synthesis and in vitro evaluation of novel dehydroabietic acid derivatives containing a dipeptide moiety as potential anticancer agents. Eur. J. Med. Chem., 2015, 89, 370?385.

[36] Shi-Xian Hua, Ri-Zheng Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang*, Heng-Shan Wang*, Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents. Eur. J. Med. Chem., 2015,95, 435?452.

[37] Xiaochao Huang, Rizheng Huang, Zhixin Liao, Yingming Pan, Shaohua Gou*, Hengshan Wang*. Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. Eur. J. Med. Chem., 2016, 108, (27), 381-391

[38] Xiao-Chao Huang, Meng Wang, Ying-Ming Pan, Gui-Yang Yao, Heng-Shan Wang*, Xiao-Yan Tian, Jiang-Ke Qin, Ye Zhang. Synthesis and antitumor activities of novel thiourea α-aminophosphonates from dehydroabietic acid. Eur. J. Med. Chem., 2013, 69, 508–520.

[39] Le Jin, Rizhen Huang, Xiaochao Huang, Bin Zhang, Min Ji? and Hengshan Wang?, Discovery of 18β-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90–Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance. Bioorganic & Medicinal Chemistry, 2018, 26, 1759–1775

[40] Huang, R. Z., Zhang, B., Huang, X. C., Liang, G. B., Qin, J. M., Pan, Y. M.,Liao Z-X * & Wang, H. S.* (2017). Synthesis and biological evaluation of terminal functionalized thiourea-containing dipeptides as antitumor agents. RSC Advances, 2017, 7(15), 8866-8878

[41] Qiang Wu, Pei Liu, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. Cu (otf) 2-catalyzed three-component annulation reaction: One-pot synthesis of 4, 5-dihydropyrazole from aldehydes, hydrazines and alkenes. RSC Advances. 2012, 2: 10167–10170.

[42] Huang, R. Z., Wang, C. Y., Li, J. F., Yao, G., Pan, Y. M., Ye, M. Y., Wang, H. S.* & Zhang, Y*. (2016). Synthesis, antiproliferative and apoptosis-inducing effects of novel asiatic acid derivatives containing α-aminophosphonates. RSC Advances .2016, 6, 62890–62906.

[43] He, Y., Xie, Y. Y., Wang, Y. C., Bin, X. M., Hu, D. C., Wang, H. S.*, & Pan, Y. M*. (2016). TEMPO-catalyzed synthesis of 5-substituted isoxazoles from propargylic ketones and TMSN. RSC Advances, 2016, 6(64), 58988-58993.

[44] Wei-Gen Huang, Heng-Shan Wang*, Guo-Bo Huang, Yong-Ming Wu, Ying-Ming Pan*. Enantioselective friedel–crafts alkylation of n‐methylindoles with nitroalkenes catalyzed by chiral bifunctional abietic‐acid‐derived thiourea‐ZnII complexes. Eur. J. Org. Chem., 2012, 29, 5839–5843.

[45] Gui-Yang Yao, Ya-Jun Li, Yong-Tao Zhu, Ying-Ming Pan, Fu-Ping Huang, Hengshan Wang*, Zhi-Xin Liao*. Protonation-controlled axial chirality in maleopimaric imides.New J. Chem., 2014, 38, 693699.

[46] Gui-yang Yao, Man-yi Ye, Ri-zhen Huang, Ya-jun Li, Yong-tao Zhu, Ying-ming Pan, Zhi-Xin Liao*, Heng-shan Wang*. Synthesis and antitumor activity evaluation of maleopimaric acid N-aryl imide atropisomers.Bioorg. Med. Chem. Lett., 2013, 23, 6755-6758

[47] Gui-Yang Yao, Man-Yi Ye, Ri-Zhen Huang, Ya-Jun Li, Ying-Ming Pan, Qing Xu, Zhi-Xin Liao*, Heng-Shan Wang*. Synthesis and antitumor activities of novel rhein α-aminophosphonates conjugates. Bioorg. Med. Chem. Lett., 2014, 24, 501–507

[48] Xiao-Chao Huang, Meng Wang, Heng-Shan Wang, Zhen-Feng Chen, Ye Zhang*, Ying-Ming Pan*. Synthesis and antitumor activities of novel dipeptide derivativesderived from dehydroabietic acid. Bioorg. Med. Chem. Lett., 2014, 24, 1511–1518.

[49] Xiao-Chao Huang, Meng Wang, Ying-ming Pan, Xiao-Yan Tian, Heng-shan Wang*, Ye Zhang*. Synthesis and antitumor activities of novel α-aminophosphonates dehydroabietic acid derivatives. Bioorg. Med. Chem. Lett., 2013, 23(19), 5283–5289.

[50] Pan, Yingming*; He, Chunhuan; Wang, Hengshan*; Ji, Xiaowen; Wang, Kai; Liu, Peizhen Antioxidant activity of microwave-assisted extract of Buddleia officinalis and its major active component. Food Chemistry, 2010, 121, 15, 497–502

[51] Yingming Pan,*, Zhiren Zhu, Zhili Huang, Hengshan Wang*, Ying Liang, Kai Wang, Qian Lei, Min Liang. Characterisation and free radical scavenging activities of novel red pigment from Osmanthus fragrans’ seeds. Food Chemistry, 2009, 112909–913

[52] Yingming Pan*, Kai Wang, Siqin Huang, Hengshan Wang*, Xiaomei Mu, Chunhuan He, Xiaowen Ji, Jie Zhang and Fujuan Huang. Antioxidant activity of microwave- assisted extract of longan (Dimocarpus Longan Lour.) peel.Food Chemistry,2008, 1063):1264-1270

[53] Yingming Pan*, Jinchan Zhu, Hengshan Wang*, Xiaopu Zhang, Ye Zhang, Chunhuan He, Xiaowen Ji, Haiyun Li. Antioxidant activity of ethanolic extract of Cortex fraxini and use in peanut oil.Food Chemistry,2007, 103: 913–918

[54] Yingming Pan*, Xiaopu Zhang, Hengshan Wang*, Ying Liang, Jinchan Zhu, Haiyun Li, Zhi Zhang, Qingmao Wu. Antioxidant potential of ethanolic extract of Polygonum cuspidatum and application in peanut oil. Food Chemistry, 2007, 105 (4):1518-1524

[55] Heng-Shan Wang*, Dian-Hua Gan, Xiao-Pu Zhang, Ying-Ming Pan. Antioxidant capacity of the extracts from pulp of Osmanthus fragrans and its components. LWT - Food Sci. Technol. 2010, 43, 319–325.

[56] Ming-Xiong Tan, Dian-hua Gan, Liu-xin Wei, Ying-ming Pan, Shao-qing Tang, Heng-shan Wang*. Isolation and characterization of pigment from Cinnamomum burmannii’peel. Food Res. Int. 2011, 44: 2289–2294.

[57] Pan, Q. M., Li, Y. H., Hua, J., Huang, F. P., Wang, H. S., & Liang, D. (2015). Antiviral Matrine-type Alkaloids from the Rhizomes of Sophora tonkinensis. J. Nat. Prod., 78(7), 1683-1688.

[58] Heng-Shan Wang*, Xiao-Yan Tian, Da Yang, Ying-Ming Pan, Qiang Wu, Chun-Huan He. Synthesis and enantiomeric recognition ability of 22-crown-6 ethers derived from rosin acid and BINOL. Tetrahedron: Asymmetry, 2011, 22(4), 381–386.

[59] Qi Gao, Shen-Yan Li, Ying-Ming Pan*, Yan-Li Xu, Heng-Shan Wang*. The indium-catalysed hydration of alkynes using substoichiometric amounts of PTSA as additive. Tetrahedron, 2013, 69(19), 3775–3781.

[60] Pei Liu, Ying-Ming Pan*, Kun Hu, Xiao-Chao Huang, Ying Liang, Heng-Shan Wang*. Ligand-free indium(III)-catalyzed Heck reaction.Tetrahedron, 2013, 69(37), 7925–7930.

[61] Ying-Chun Wang, Heng-Shan Wang*, Guo-Bao Huang, Fu-Ping Huang, Kun Hu, Ying-Ming Pan*. A one-pot approach to 4,5-dihydropyrazoles from ketones, arylacetylenes, and hydrazines. Tetrahedron, 2014, 70, 1621–1628.

[62] Lu-Zhi Liu, Chun-Huan He, Lin Yang, Yan Huang, Qiang Wu, Wen-gui Duan, Heng-shan Wang*, Ying-ming Pan*. Novel C1-symmetric chiral crown ethers bearing rosin acids groups: synthesis and enantiomeric recognition for ammonium salts. Tetrahedron, 2014, 70, 9545–9553.

[63] Le Jin, Hong-En Qu, Xiao-Chao Huang, Ying-Ming Pan, Dong Liang, Zhen-Feng Chen, Heng-Shan Wang,* and Ye Zhang*. Synthesis and Biological Evaluation of Novel Dehydroabietic Acid DerivativesConjugated with Acyl-Thiourea Peptide Moiety as Antitumor Agents, Int. J. Mol. Sci.2015, 16, 14571-14593.

[64] Man-Yi Ye, Gui-Yang Yao, Jing-Chen Wei, Ying-Ming Pan*, Zhi-Xin Liao, Heng-Shan Wang*. Synthesis, cytotoxicity, DNA binding and apoptosis of rhein phosphonate derivatives as antitumor agents. Int. J. Mol. Sci., 2013, 14, 9424–9439.

[65] Yajun Li, Caiyi Wang, Manyi Ye, guiyang yao*, Heng-Shan Wang*. Novel coumarin-containing aminophosphonates as antitumor agent: Synthesis, cytotoxicity, DNA-binding and Apoptosis evaluation. Molecules,2015, 20, 14791-14809

[66] Ying-Chun Wang, Lu-Zhi Liu, Ying-Ming Pan, Heng-Shan Wang*. Synthesis of a Dehydroabietyl Derivative Bearing a 2-(2′-Hydroxyphenyl) Benzimidazole Unit and Its Selective Cu2+ Chemosensing. Molecules, 2011, 16(1), 100–106.

[67] Yao, G., Ye, M., Zhu, Y., Liao, Z.*, & Wang, H.* Synthesis and pharmacological evaluation of maleopimaric N-arylimides: Identification of novel proapoptotic agents, Anti-Cancer Agent. Med. Chem., 2016, 16(6), 755-762

[68] Huang, R. Z., Hua, S. X., Wang, C. Y., Pan, Y. M., Qin, J. M., Ding, Z. Y., Zhang, Y*. & Wang, H. S.*. 4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies. Anti-Cancer Agent. Med. Chem., 2017, 17(4), 576-589.

[69] Pingtan Lin, Shulin Zhao*, Xin Lu, Fanggui Ye, Hengshan Wang*. Preparation of a dual- enzyme co-immobilized capillary microreactor and simultaneous screening of multiple enzyme inhibitors by capillary electrophoresis, J. Sep. Sci., 2013, 36(15): 2538–2543.

[70] Ying-Chun Wang, Chun-Hua Su, Fang-Yao Li, Lu-Zhi Liu, Ying-Ming Pan, Xiu-Rong Wu, Heng-Shan Wang*. Syntheses, characterization and fluorescent properties of two series of dehydroabietic acid C-ring derivatives. Spectrochim. Acta A, 2010, 76, 328–335.

[71] Xi-Lin Ouyang, L-X Wei , Heng-Shan Wang*, Ying-Ming Pan*. Antioxidant activity and phytochemical composition of Osmanthus fragrans' pulps. S. Afr. J. Bot., 98 (2015) 162–166.

[72] XL Ouyang, XM Fang, YM Pan, LX Wei,HS Wang*, Development of HPLC Fingerprint for the Quality Control of Euonymus fortunei and Distinguishing from Related Species. Acta Chromatogr., 2012, 24(2): 301-316.

[73] Rui-Yun Yang, Xi-Lin Ouyang, Dian-Hua Gan, Heng-Shan Wang*, Yi-Zheng Li, Ying-Ming Pan*. Isolation and Determination of Iridoid Glycosides From the Seeds of Osmanthus fragrans by HPLC. Anal. Lett., 2012, 46: 745–752

[74] Xi-Lin Ouyang,, Liu-Xin Wei, Xian-Ming Fang, Heng-Shan Wang*, Ying-Ming Pan*. Flavonoid constituents of Euonymus fortune. Chem. Nat. Compd., 2013, 49(3), 428–431.

[75] Yi-Zheng Li, Ying-Ming Pan, Xiao-Yan Huang, Heng-Shan Wang*. Withanolides from Physalis alkekengi var. francheti. Helv. Chim. Acta. 2008, 91: 2284-2291.

[76] Hengshan Wang, Shulin Zhao*, Min He, Zhicai Zhao, Yingming Pan, Qian Liang. Sodium maleopimaric acid as pseudostationary phase for chiral separations of amino acids derivatives by capillary micellar electrokinetic chromatography. J. Sep. Sci., 2007, 30: 2748-2753.

[77] Hengshan.Wang, Rongcan Zhang, Shulin Zhao*, Lidong Tang and Yingming Pan. Synthesis and application of dehydroabietylisothiocyante as a new chiralderivatizing agent for the enantiomeric separation of chiral compounds by capillary electrophoretic. Anal. Chim. Acta 2006, 560: 64–68.

[78] Shulin Zhao*, Rongcan Zhang, Hengshan Wang*, Lidong Tang and Yingming Pan. Capillary electrophoresis enantioselective separation of vigabatrin enantiomers by precolumn derivatization. J. Chromatogr. B, 2006, 833 : 186–190.

  

---发明专利---

1王恒山; 潘英明; 黎霜. 从罗汉果残渣中提取多种成分,ZL 02133627.X2004,中国专利授权

2.王恒山; 童碧海; 潘英明. 松香基吖啶类化合物的合成、其制造方法及其用途, ZL 200410040714.12006,中国专利授权

3.王恒山; 张业; 潘英明脱氢松香酸甲酯呋咱衍生物,其合成方法及其用途,申请号:200410081396.32004,中国专利

4. 王恒山, 戴伟龙, 潘英明, 姚贵阳, 程克光, 陈振锋, 田小艳. 茜素二氧杂环己烷衍生物及其制备方法和应用. 专利号: 201210324944.5.

5. 王恒山; 潘英明; 黄卫根; 谭恒; 刘志芳; 刘陆智. 脱氢松香基硫脲衍生物及其制备方法和应用 专利号:201010284217

6. 王恒山,黄日镇,潘英明,姚贵阳,戴伟龙,叶鳗仪,陈振锋. 大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号:201310475681.2

7. 王恒山黄日镇潘英明姚贵阳戴伟龙叶鳗仪陈振锋. 双乙酰大黄酸氨基膦酸酯衍生物及其合成方法和应用. 专利号201310475685.0

8. 王恒山潘英明姚贵阳叶鳗仪, 黄日镇. 茜素氨基膦酸酯衍生物及其合成方法和应用. 专利号ZL201310730928.0

9. 王恒山,梁东,姚维娜,黄日镇,王春姑,潘英明,张斌,代禄梅。一种含吡喃环酚类化合物及其制备方法和应用,专利申请号201710053753.2


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